What is the difference between a "macule," "papule," and "vesicle"?

These terms describe primary skin lesions by their appearance. A macule is a flat, discolored area less than one centimeter in diameter, like a freckle or flat mole. If larger than one centimeter, it is called a patch. A papule is a raised, solid bump less than one centimeter, like a small wart. If larger than one centimeter, it is called a plaque or nodule. A vesicle is a small fluid-filled blister less than one centimeter, like a chickenpox lesion. If larger than one centimeter, it is called a bulla.