What are fluoroquinolones and what are their serious side effects?

Fluoroquinolones like ciprofloxacin, levofloxacin, and moxifloxacin are broad-spectrum antibiotics that inhibit bacterial DNA gyrase and topoisomerase four, preventing DNA replication. They treat urinary tract infections, respiratory infections, and abdominal infections. The FDA has issued multiple black box warnings for serious side effects including tendon rupture, especially of the Achilles tendon, peripheral neuropathy, central nervous system effects including seizures, aortic aneurysm, and hypoglycemia.