What is the mechanism of action of sucralfate?

Sucralfate is a mucosal protectant that forms a paste-like protective barrier over ulcerated tissue in the stomach and duodenum. In the acidic environment of the stomach, sucralfate polymerizes and binds to positively charged proteins at the ulcer base, creating a physical shield that prevents further acid, pepsin, and bile damage. It does not reduce acid secretion. Sucralfate must be taken on an empty stomach, one hour before meals, because food interferes with its ability to bind to the ulcer site. ---