What is the difference between opioid tolerance, dependence, and addiction?

Tolerance is a physiological adaptation where higher doses are needed to achieve the same pain relief, developing predictably with regular use. Physical dependence is a physiological state where abrupt discontinuation causes withdrawal symptoms like anxiety, sweating, nausea, and muscle aches. Addiction is a behavioral disorder characterized by compulsive drug seeking, continued use despite harm, and loss of control. Tolerance and dependence are expected pharmacological responses that occur in anyone taking opioids regularly and do not indicate addiction.