What are the signs and symptoms of Cushing syndrome from corticosteroid use?

Cushing syndrome from exogenous corticosteroid use presents with a characteristic constellation of signs including central obesity with a round "moon face" and fat deposits on the upper back called a "buffalo hump," thin fragile skin with easy bruising and purple striae, muscle weakness especially in the proximal limbs, hyperglycemia, hypertension, osteoporosis, mood changes, and immunosuppression with increased infection risk. These features develop gradually with chronic corticosteroid therapy at supraphysiologic doses.