Heparin-Induced Thrombocytopenia Explained

Heparin-induced thrombocytopenia, or HIT, is a serious immune-mediated reaction where heparin triggers antibodies that activate platelets, paradoxically causing both thrombocytopenia, meaning low platelet count, and an increased risk of blood clots. It typically occurs five to ten days after starting heparin therapy. Platelet counts drop by 50 percent or more from baseline. HIT requires immediate discontinuation of all heparin products including heparin flushes and transition to an alternative anticoagulant such as argatroban or bivalirudin.