How do SNRIs differ from SSRIs?

Serotonin-norepinephrine reuptake inhibitors, or SNRIs, block the reuptake of both serotonin and norepinephrine, whereas SSRIs block only serotonin reuptake. Common SNRIs include venlafaxine, duloxetine, and desvenlafaxine. The dual mechanism makes SNRIs effective for depression with prominent fatigue and pain symptoms. Duloxetine is also approved for diabetic neuropathy, fibromyalgia, and chronic musculoskeletal pain. Side effects are similar to SSRIs but can include elevated blood pressure at higher doses due to norepinephrine effects.